Former Wales captain Sam Warburton thinks his side will be up against it at Twickenham on Saturday.
Canterbury ambassador Warburton said: “Going away to Twickenham might actually work in Wales’ favour, England being semi-finalists in the World Cup, and going away from home then I think the pressure is off.
“But people will still be thinking England should put Wales to the sword given that Scotland beat them.
“England are red-hot favourites, Wales haven’t won there since 2012 and before that in the Six Nations it was 2008. They were both Grand Slam teams who won at Twickenham. You don’t win at Twickenham as an average team.
“The odds are stacked against Wales, Twickenham was one of my favourite places to play but it was always so hard. If I was a betting man I’d go with England.”